When Boris (Jason Alexander), Natasha (Rene Russo) and Fearless Leader (Robert De Niro) take over numerous television networks with the goal of hypnotizing American viewers, young FBI investigator Karen Sympathy (Piper Perabo) tries to stop them with the help of sharp-tongued Rocky and dim-witted Bullwinkle. John Goodman, Carl Reiner, Randy Quaid, David Alan Grier, Janeane Garofalo and Billy Crystal co-star in this mixed live action-animated comedy.